We face Xabi Alonso’s side at 20:00 (UK) on Wednesday 10 December aiming for a positive result in our bid for the progress through to the Round of 16.
Pep Guardiola’s side have won three, drawn one and lost one in our five matches in the European competition, which means we sit ninth with ten points accrued so far.
We also head to the Bernabeu on the back of successes over Leeds, Fulham and Sunderland domestically.
Meanwhile, the hosts sit comfortably in fifth on 12 points, winning four out of their five games in the competition.
With an all important spot in the top eight at stake, it all points to an exciting head to head in Spain that will have fans reminiscing of previous clashes.
First in our roundup of our best moments against Los Blancos, we head back to 2012/13 as we played out a 1-1 draw in the Group Stage at the Etihad.
That’s followed up by a 4-3 victory in the semi-final during the 2021/22 season which saw Kevin De Bruyne, Gabriel Jesus, Phil Foden and Bernardo Silva on the scoresheet.
We then finish things with another semi-final, this time in 2022/23 as City came out 4-0 winners in Manchester and progressed to the Champions League final in what must go down as one of our greatest ever nights.
Take a trip down memory lane at the top of the page...
