The Blues suffered a 2-1 loss at Old Trafford after a late comeback from the hosts following a Jack Grealish header.
However, Guardiola, who today celebrates his 52nd birthday, ordered his side to move on from that disappointment.
With Antonio Conte’s Spurs in fifth place in the Premier League, the boss knows we will have to be at our best to claim the three points at the Etihad Stadium.
“It’s over. It is the past,” said Guardiola when asked about his reflections on the Manchester derby.
“We are not going to change anything now so focus on Tottenham.
“Two minutes later in the dressing room that was my message to the team. Focus against Tottenham.
“We have to improve our game and gain control. This is what big teams have to do.
“To create chances you have to play good. Make a good build-up, put the ball inside, spread the defensive lines. We struggled to do that in the last two games.”
Click on the video above to hear everything Guardiola said...
City v Spurs
You can follow the match across mancity.com and our official app.
Our Matchday Centre begins coverage at 18:00 with live text updates throughout the night.
Matchday Live will start just before 19:00 in order to bring the team news immediately. Cel Spellman will be joined by Michael Brown, Paul Dickov and Steve Howey for that one.
For the match itself, Alistair Mann and Andy Morrison will provide radio commentary.
After the game, we will have full reaction from the manager, a player and then highlights at midnight.