City travel to Kenilworth Road for the 20:00 (UK) with a result guaranteed on the night with extra-time and penalties if required.
After back-to-back 1-0 victories over Brentford and Bournemouth in the Premier League, the boss is expecting a similarly tough test against the Hatters.
Goals for Bernardo Silva and Jack Grealish saw us come from behind to win 2-1 in December and all the top sides have found it difficult at Luton’s home.
With games against Manchester United, Liverpool, Brighton and Arsenal in March, as well as the potential of more cup games, Guardiola says they are coming to the key part of the season.
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“I don’t have any doubts we’re going to try,” he said at his prematch news conference. “After the game February is over, just two months or three months to the end of the season, we arrive here still being there.
“Tomorrow is a final like every game in the Premier League and of course in the Champions League, so the decisive period of the season is here in front of us. Not far away in front if us and we’re going for it.
“Of course, when you play in the last-16 and semi-finals and you know how difficult it is.
“It’s a good test to see how our rhythm, our mental consistency is, to what we have for the next month and everybody knows what we are going to play for.”
Watch the first part of Pep’s press conference in the video above...
