We face the German outfit on Tuesday, with a 20:00 (UK) kick-off at the Etihad Stadium.
The winners will go through to the quarter-finals of the competition.
As he looks to lock horns with Marco Rose again, Guardiola also spoke of needing to play a ‘solid game’ to progress.
He said: “I don’t pay any attention to what happened there.
“The first half we were better, second half they were better.
“We are going to play a solid game and adjust a few things to have more control and be better.
“Always I believe that transition games is a [toss of the] coin. It can go in your favour.
CITY V LEIPZIG | MATCH PREVIEW
“In a knockout game the game can dictate what you have to do. We will see at the end.”
Leipzig could be without Xaver Schlager and Christopher Nkunku this week after both picked up injuries in Friday’s 2-1 defeat to Borussia Dortmund.
Schlager was forced off towards the end of the game with ligament problems and underwent an operation in Munich, which could see him out for a significant period.
Nkunku suffered a minor thigh strain and is also now set for a spell on the sidelines.
Guardiola says, despite these possible absences, Leipzig will be formidable opponents.
He added: “They are so aggressive in the high pressing.
“They have incredible build-up from the central defenders and goalkeeper.
“They play eight players inside and two incredible wide full-backs. When you close outside they have players inside. That’s why it’s so difficult to control them.
“Nkunku is exceptional player but they live this season without him and do it really well without him.
CITY V LEIPZIG | GUARDIOLA PREVIEW
“We will try to find our spaces and players to punish them.
“We have to win the game and to win the game we have to try.
“I admire a lot what Leipzig have done. When I was in Munich they were in second division so I could not face them. I am a big fan of what they do.”
Watch the press conference in the video player above.
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