The match, played at Kingsmeadow, will kick-off at 19:15(UK) and while it won’t decide the title, it could define the title race.
Gareth Taylor‘s side are in red-hot form and could go top with a victory - and would have just eight games remaining.
But Emma Hayes’ wily troops have been a powerhouse in women’s football for many years and will attempt to use that experience to their advantage.
City were desperately unlucky not to have won the first clash between the two teams, with the Blues - down to nine players - only denied a famous win by an equaliser six minutes into added time.
That game ended 1-1 at the Joie Stadium.
Now, it’s time to do it all over again - so get into the mood for Friday evening’s top of the table match by watching the video above...