The champions, who were 5-0 winners when the two sides met earlier this season at the Etihad Stadium, are 1/2 to collect all three points while a repeat of that scoreline is 45/1 with online betting partners Paddy Power.
City took the lead shortly before half time through David Silva and the Spaniard is 15/2 to again be the game’s first goalscorer and 23/10 to score at anytime over the 90 minutes.
Silva is one of the players up for February’s Player of the Month award having provided eight assists in City’s nine goals over the past few weeks.
Sergio Aguero (2) and Carlos Tevez (2) scored the goals in a 20-minute second-half spell against Villa and Paddy Power make both 7/2 to score two or more goals against Paul Lambert’s struggling side.
Mancini’s men to win both halves is an 11/4 chance while the Blues to win to nil is 6/4.
Title-chasing City won this fixture 1-0 last season thanks to Joleon Lescott’s 63rd-minute winner and the defender is 25/1 to score the first goal or 25/1 to score the last goal of the game against the Villains.
A 2-0 win against Chelsea in the Barclays Premier League last weekend with Yaya Toure opening the scoring and Tevez netting the crucial second goal in the 85th-minute widened the gap between the champions and the rest of the chasing pack.
Toure – who was scoring his second goal in three games since returning from the African Cup of Nations with the Ivory Coast - is 23/10 to score at anytime against Villa.
Toure is 15/2 to get the opening goal of the game at Villa Park or 5/1 to score first for his side on Monday night.
City to win and Toure to score at anytime is 11/4 in Paddy Power’s Wincast market.
The Blues biggest victory on their travels was a 3-1 win at Newcastle United last December with Sergio Aguero, Javi Garcia and Toure again among the goals.
To win 3-1 against Villa is 10/1 while City to score three or more goals in Paddy Power’s team goals in match market is 7/4. Villa v City – Bet £10 Get £20 Free!
