Patrick Vieira‘s men last tasted defeat in the league back in October and have won their last nine games on the bounce.
Their recent successes have seen the Blues climb to fifth in the Barclays Under-21 Premier League table, trailing table-toppers Fulham by six points but with a game in hand.
Last time out, the Blues smashed in-form Bolton with goals from Seko Fofana, Sinan Bytyqi, Devante Cole and Jordi Hiwula securing a 4-0 win.
Last weekend, their Premier League Cup quarter-final clash with Wolves was postponed so they will have had a week’s rest over the Blues.
With City on such a scintillating run, Vieira’s men will be looking to return to Manchester with a victory as they bid to reach the league summit.
Kick-off is at 1pm GMT behind closed doors at Reading’s training ground. We’ll have live updates on Twitter, plus a full-match report on mcfc.co.uk.