Coach Andy Welsh will be hoping City can bounce back from their 1-0 home Lancashire Senior Cup loss to Liverpool last week and resume their challenge for the Barclays Premier Reserve League North title.
The Blues currently sit in fourth position but have three games in hand over the Magpies and a victory will see City close the gap between the clubs to just three points.
Michael Johnson is expected to continue his comeback after two recent 45-minute stints with the EDS and could possibly step up his playing time for the visit of Newcastle.
The visitors beat City 1-0 in the north east last November and won their last game against Wigan Athletic reserves 5-1.
With several members of the team that thrashed the Latics now loaned out to various clubs and the first team enjoying a four-day break, Newcastle coach Beardsley may be forced to play a younger starting eleven than he would have liked.
Former Everton midfielder Dan Gosling may continue his comeback against City having been missing for most of the season with a ruptured cruciate ligament, though England striker Andy Carroll is unlikely to feature as part of his recovery from a thigh strain.
Another good crowd is expected with admission prices just £3 for adults and £1 for concessions. There will be 5 loyalty points added for this fixture but please remember to bring your seasoncard with you.
With the City first team now in action against Birmingham next Wednesday, the home Manchester Senior Cup tie with Bury will now be played a day later on Thursday, February 3, kick-off 7pm.