With the Europa League and the Carling Cup kicking in early in the season the manager knows he will need a substantial squad from flag fall.
And the Blues boss admits he is ready to chop and change his starting line up in a bid to avoid fatigue to both bodies and minds.
“We want to make progress in as many competitions as possible and that will mean playing a lot on a Thursday night,” he noted.
“You cannot play in the Premier League on a Saturday, then in Europe on a Thursday before coming back on Friday and be properly ready in two days for a Sunday game.
“That is why it is important to have an experienced squad with many good players in it. Of course every player wants to start every match, that is natural and I was the same, but it is not possible. Some players may have to change their mentality.
“They will have to accept that and understand that sometimes it is best to rest.”
Mancini has today welcomed England goalkeeper Joe Hart back into the squad and will have the Toure brothers, Shaun Wright-Phillips and Gareth Barry in harness before the tournament in New York.
David Silva, Nigel de Jong and Jerome Boateng will be on holiday a little longer after reaching the latter stages of the World Cup.