The City duo have featured regularly for the Three Lions under Roy Hodgson, and both won starting berths in England’s last outing, a 2-2 draw against Brazil in the Maracana Stadium in June.
Joe will be looking to win his 33rd cap for his country aged just 26, while Milner has collected 38 international caps during his career.
This is the first time that the two teams have met since 1999, when England won 2-1 on aggregate over two games to earn qualification for Euro 2000, and forms part of the FA’s 150th anniversary celebrations.
Full squad to face Scotland:
Ben Foster, Joe Hart, John Ruddy; Leighton Baines, Gary Cahill, Ashley Cole, Phil Jagielka, Glen Johnson, Phil Jones, Chris Smalling, Kyle Walker; Michael Carrick, Tom Cleverley, Steven Gerrard, Frank Lampard, Jack Wilshere, James Milner, Alex Oxlade-Chamberlain, Theo Walcott, Ashley Young, Wilfried Zaha;
Jermain Defoe, Rickie Lambert, Wayne Rooney, Danny Welbeck.
Elsewhere, Samir Nasri and Gael Clichy have both been recalled for the France squad for their friendly against Belgium.
It means that Samir will have his first chance to play for Les Bleus since Euro 2012.
“Last season Nasri was not really eligible because he was injured and did not play a lot. He has to understand that he is eligible,” said France Head Coach Didier Deschamps.
Vincent Kompany has been named in that Belgium squad which will provide the opposition.
EDS midfielder Emyr Huws has also been called up for Wales u21s for their UEFA qualifying game against Finland at Bangor City’s BookPeople Stadium.
Yaya Toure has been named in the Ivory Coast squad to face Mexico alongside City teammate Abdul Razak. The two teams will meet in New York.
Any other international call-ups will appear here on this page as soon as we receive notification.
