A point will secure first place, but it would need a high-scoring win for either Chile or Panama in their meeting to knock the Albiceleste off their perch if they were to lose to their land-locked South American neighbours.
With Argentina having eased to victory over Chile and then Panama, there is a chance that coach Gerardo Martino may shuffle his pack and give Sergio Aguero his first start of the tournament.
The striker appeared late on in Argentina’s first two outings, scoring the final goal of the 5-0 drubbing of Panama.
Nicolas Otamendi has started both games, scoring only his second international goal to start the rout of the Panamanians.
Bolivia will be itching to leave the tournament with something to show, having slipped to 2-1 defeats to both Chile and Panama courtesy of late winners in both matches.
But Aguero will be keen to lock horns with Bolivia at the Centurylink Field, having bagged a hat-trick and then two more in 5-0 and 7-0 thrashings within the last 12 months.
The winners of Group D face the runners-up in Group C, which will be Venezuela following their 1-1 draw with Mexico.
