Jesus Navas comes into the side, with Ivorian midfielder Yaya Toure on the bench. Defender Vincent Kompany returns to the matchday squad following his recovery from injury.
Team
City XI: Caballero, Sterling, Aguero, Navas, De Bruyne, Sane, Silva (c), Clichy, Stones, Fernandinho, Otamendi
Subs: Bravo, Kompany, Zabaleta, Nolito, Kolarov, Delph, Toure
Tactics
It looks like versatile Brazilian Fernandinho will be employed at right back, with Gael Clichy continuing on the left and Nicolas Otamendi and John Stones in the centre of defence.
A notable inclusion on the bench is skipper Kompany, who is back in the matchday squad for the first time since the game at Bournemouth on February 13.
Predicting the midfield formation can be a tricky task. David Silva and Kevin De Bruyne should occupy central roles, while Raheem Sterling might come off his usual wing posting and play in a more advanced position, with Leroy Sane and Navas on the flanks.
Sergio Aguero will spearhead the attack looking to add to his tally of 25 goals in all competitions this season.
Arsenal XI: Ospina, Mustafi, Koscielny, Bellerin, Monreal, Xhaka, Coquelin, Walcott, Ozil, Alexis, Welbeck
Subs: Martinez, Gibbs, Gabriel, Elneny, Maitland-Niles, Iwobi, Giroud.