The skipper is one of two changes to the side that drew at Arsenal on Sunday, with Fabian Delph also back in the starting line up.
City XI: Caballero, Kompany (c), Aguero, Navas, De Bruyne, Delph, Sane, Silva, Clichy, Stones, Fernandinho
Subs: Bravo, Zabaleta, Fernando, Sterling, Nolito, Kolarov, Toure
Tactics
Kompany will slot straight back into the centre of defence, for his first appearance since the win over Crystal Palace on 28 January.
Then it gets interesting! If Pep Guardiola chooses to employ Fernandinho at right back, Delph should slot into the holding role, with Jesus Navas on the right wing.
If Navas takes the right back position again, Fernandinho would likely move into the holding midfield role, with Leroy Sane and Delph taking the wider positions.
Up front Sergio Aguero will look to add to his tally of 26 goals.
Chelsea: Courtois; Zouma, David Luiz, Cahill (c); Azpilicueta, Kante, Fabregas, Alonso; Pedro, Diego Costa, Hazard
Subs: Begovic, Ake, Terry, Matic, Loftus-Cheek, Willian, Batshuayi