Claudio Bravo, Raheem Sterling, Aleks Kolarov and Yaya Toure return to the starting XI in place of Willy Caballero, Kevin De Bruyne, Vincent Kompany and Fernandinho.
Bacary Sagna, Nicolas Otamendi, Gabriel Jesus and Ilkay Gundogan miss out through injury, while Fernandinho is rested.
City XI: Bravo, Clichy, Stones, Navas, Kolarov, Toure, Delph, Sterling, Silva (c), Sane, Aguero.
Subs: Caballero, Kompany, Zabaleta, Fernando, Nolito, De Bruyne, Iheanacho.
Tactics
With City likely to adopt a 4-1-4-1 formation, Bravo will be shielded by a backline of Gael Clichy, Kolarov, John Stones and stand-in right-back Jesus Navas.
Toure or Fabian Delph will be employed in the defensive midfield role, while the other will accompany David Silva in the middle. Leroy Sane and Sterling will operate on the wings.
Sergio Aguero leads the line upfront, seeking to add to his tally of 27 goals and run of nine in nine games.
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Hull XI: Jakupovic, Robertson, Dawson, Ranocchia, Elmohamady, Grosicki, N’Diaye, Clucas, Markovic, Evandro, Niasse.
Subs: Marshall, Meyler, Davies, Hernández, Maloney, Diomande, Henriksen