Vincent Kompany, Nicolas Otamendi, Fernandinho and Kevin De Bruyne return to the starting XI in place of John Stones, Aleks Kolarov, Raheem Sterling and Fabian Delph.
Stones, Delph, Bacary Sagna, Gabriel Jesus and Nolito is rested.
City XI: Bravo, Clichy, Kompany (c), Otamendi, Fernandinho, Toure, Sane, Silva, De Bruyne, Navas, Aguero.
Subs: Caballero, Zabaleta, Kolarov, Fernando, Sterling, Garcia, Iheanacho.
Tactics
With City likely to adopt a 4-1-4-1 formation, Claudio Bravo will be shielded by a backline of Gael Clichy, Otamendi, captain Kompany and stand-in right-back Jesus Navas.
Fernandinho will be employed in the defensive midfield role, while Yaya Toure will accompany David Silva in the middle. Leroy Sane and De Bruyne will operate on the wings.
Sergio Aguero leads the line upfront, seeking to add to his tally of 28 goals and run of ten in ten games.
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— Manchester City (@ManCity) April 15, 2017
Southampton XI: Forster, Cedric, Stephens, Yoshida, Bertrand, Davis (c), Hojbjerg, Ward-Prowse, Tadic, Redmond, Gabbiadini.
Subs: Hassen, Martina, Caceres, Clasie, Boufal, Long, Rodriguez.
