Only Leroy Sane and John Stones retain their place with seven of the Carabao Cup side from midweek starting on the bench.
Kevin De Bruyne (injured) and Brahim Diaz miss out today.
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Team:
Ederson, Walker, Stones, Laporte, Mendy, Fernandinho, D Silva (c), Bernardo, Sane, Sterling, Aguero
Subs: Muric, Danilo, Kompany, Delph, Mahrez, G Jesus, Foden
Probable formation:
Hard to imagine anything other than 4-3-3 this afternoon.
The defensive back-line is set in stone with Fernandinho in front and David and Bernardo Silva the attacking midfielders.
Raheem Sterling and Leroy Sane will flank and support Sergio Aguero in attack.
Southampton starting XI:
To follow…
The last time...
Blues look to go clear?
Liverpool’s draw with Arsenal yesterday evening allows Pep Guardiola’s men the opportunity to go clear at the top of the Premier League for the first time this season.
Chelsea face Crystal Palace in today’s later kick-off and victory for the Pensioners will see them move to second in the table, should City beat Southampton.
Stats and possible milestones
If Ederson keeps a clean sheet this afternoon, it will be his seventh Premier League shut-out in succession and become a new Club record.
Sergio Aguero remains one goal short of a 150 Premier League landmark – if he manages that today, he’ll become only the third City player to achieve the feat behind Tom Johnson (158) and Eric Brook (158).
The Blues are looking to win a sixth consecutive Premier League home game this season and preserve a 100% record at the Etihad.
The Blues have won seven out of the last nine Premier League meetings with Saints.
Last season, City needed two added time winners to overcome Southampton.
Pep Guardiola and Mark Hughes have both played for Barcelona and managed City.
