The Argentine missed our last two matches after limping out of the win away at Fulham 10 days ago but has fully recovered and leads the line at the Tottenham Hotspur Stadium.
He will be looking to add to his 29 goals this season, five of which have come in the UEFA Champions League.
Kyle Walker is also fit enough to play. He came off at half-time of Saturday’s FA Cup semi-final with a hamstring problem but has made a quick recovery.
Benjamin Mendy misses out after making his first appearance since January and is replaced by Fabian Delph.
Bernardo Silva and Gabriel Jesus are replaced by Riyad Mahrez and Fernandinho as Pep Guardiola makes four changes from Wembley.
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City team
XI: Ederson, Walker, Otamendi, Laporte, Delph, Fernandinho, Gundogan, Silva, Mahrez, Sterling and Aguero
Subs: Muric, Kompany, Stones, De Bruyne, Sane, Jesus, Foden
City tactics
Guardiola never reverts from 4-3-3, with the focus on dominating possession and attacking the opposition whenever possible.
Walker and Delph will need to get forward and add width. Nicolas Otamendi and Aymeric Laporte continue together at the heart of the City defence after another solid showing on Saturday.
Fernandinho will anchor the midfied and sit just in front of the centre-halves, with Ilkay Gundogan and David Silva free roam.
Mahrez and Raheem Sterling, who has 19 goals this term, will support Aguero.
City need to weather the early storm from a side who traditionally start quickly.
Spurs team
#THFC: Lloris (C), Trippier, Alderweireld, Vertonghen, Rose, Sissoko, Winks, Eriksen, Dele, Son, Kane #UCL ⚪️ #COYS pic.twitter.com/Mlw8qA5vqp
— Tottenham Hotspur (@SpursOfficial) April 9, 2019
Match stats
Tottenham Hotspur and Manchester City have been contenders at the top of the Premier League in recent years and now translate their rivalry to the European stage for the first time.
This is Tottenham’s first European game in their new stadium; their first four home UEFA Champions League games this season were played at Wembley.
While Spurs are in the UEFA Champions League quarter-finals for the first time since their sole previous appearance eight years ago, this is City’s third last-eight tie in the past four seasons – and a second successive contest at this stage against a fellow English club.
Both come into this match buoyed by positive round of 16 performances against German opponents, Spurs seeing off Borussia Dortmund 4-0 on aggregate while City recorded their biggest European victory last time out, dismantling Schalke 7-0 in Manchester to complete a 10-2 success over the two legs.
There has been very little between Tottenham and City in domestic football over the years. In 156 competitive meetings, City have won 61 to Spurs’ 60, with 35 draws – although City have won the last three fixtures between the sides.
In this season’s Premier League, a sixth-minute Riyad Mahrez goal proved enough for City to pick up three points against Spurs at Wembley on 29 October. The league game at the City of Manchester Stadium is scheduled for 20 April – three days after the second leg of this tie.
In English domestic knockout football, Spurs have won nine of the teams’ 14 ties – including five of the last six.
Tottenham have not faced an English team in a European competition since April 1973, when they faced - and were eliminated by - Liverpool in the 1972-73 UEFA Cup semi-final.
Manchester City have lost all four of their European matches against English opponents, losing both legs of the 1970-71 Cup Winners’ Cup semi-final against Chelsea and both legs of last season’s Champions League quarter-final against Liverpool.
This is the first ever European meeting between Tottenham Hotspur and City in what is the 157th meeting between the teams in all competitions.
City have won 11 of their last 16 matches against Spurs (D1 L4), with all those meetings coming in the Premier League.
Spurs are competing in only their second Champions League quarter-final, losing previously 0-5 on aggregate to Real Madrid in 2010-11.
Tottenham striker Harry Kane has been involved in 17 goals in 17 Champions League appearances (14 goals, 3 assists).
City boss Pep Guardiola has won 26 of his 52 Champions League knockout matches, just one behind the all-time record held jointly by Sir Alex Ferguson, Jose Mourinho and Carlo Ancelotti (27 wins).
