Gabriel Jesus and Phil Foden are among eight changes to the side that beat Liverpool on Thursday evening.
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Rotherham maybe struggling in the Championship near the foot of the table, but they are a very organised and hard-working side.
The Millers play good football and will come to the Etihad and have a go – make no mistake about that – and they have tended to play well this campaign against teams higher in the league.
Draws against Sheffield United and Swansea Birmingham and Middlesbrough prove that they can be dogged and rise to the occasion when needed.
Stats and milestones
City’s 2-1 win over Liverpool was Pep Guardiola‘s 100th victory in all competitions as Blues’ boss.
The only previous time Rotherham drew City in the FA Cup was in 1978/79 when the Millers pulled off a shock 0-0 draw at Maine Road before City won the return at Millmoor 4-2.
Club links include former players Shaun Goater, Gerry Gow and Nigel Johnson plus Millers’ ex-EDS striker Devante Cole.