Leroy Sane and Ilkay Gundogan are set to be the first City players in international action this week when Germany take on Serbia in a friendly tonight, 7:45pm kick-off.
A total of 13 City players have been called up to their respective nations.
The international fixtures include UEFA EURO qualifiers, friendlies, Africa Cup of Nations qualifiers and some important Under-21 and Under-19 fixtures.
Here is the full list of who is playing, when and who against:
England
Games:
England v Czech Republic (UEFA EURO qualifier)
Friday, 22 March, 7:45pm
Montenegro v England (UEFA EURO qualifier)
Monday, 25 March, 7:45pm
Germany
Games:
Germany v Serbia (friendly)
Wednesday, 20 March, 7:45pm
Netherlands v Germany (UEFA EURO qualifier)
Sunday, 24 March, 7:45pm
Brazil
Ederson, Danilo, Gabriel Jesus
Games:
Brazil v Panama (friendly)
Saturday, 23 March, 5pm
Czech Republic v Brazil (friendly)
Tuesday, 26 March, 7:45pm
Portugal
Games:
Portugal v Ukraine (UEFA EURO qualifier)
Friday, 22 March, 7:45pm
Portugal v Serbia (UEFA EURO qualifier)
Monday, 25 March, 7:45pm
Ukraine
Games:
Portugal v Ukraine (UEFA EURO qualifier)
Friday, 22 March, 7:45pm
Luxembourg v Ukraine (UEFA EURO qualifier)
Monday, 25 March, 7:45pm
Algeria
Games:
Algeria v Gambia (Africa Cup of Nations qualifier)
Friday, 22 March, 7:45pm
Algeria v Tunisia (friendly)
Tuesday, 26 March, TBC
Kosovo
Games:
Kosovo v Denmark (friendly)
Thursday, 21 March, 6pm
Kosovo v Bulgaria (UEFA EURO qualifier)
Monday, 25 March, 7:45pm
England U21s
Games:
England U21s v Poland U21s (friendly)
Thursday, 21 March, 7:45pm
England U21s v Germany U21s (friendly)
Tuesday, 26 March, 7:45pm
Spain Under-19s
Games:
Spain U19s v Slovenia U19s (EURO U19 qualifier)
Wednesday, 20 March, 3:30pm
Spain U19s v Wales U19s (EURO U19 qualifier)
Saturday, 23 March, 12noon
Netherlands U19s v Spain U19s (EURO U19 qualifier)
Tuesday, 26 March, 6pm