Fernandinho will slot into the back four against his former club Shakhtar as Pep Guardiola makes four changes from the side beaten by Norwich last weekend.
Riyad Mahrez, Gabriel Jesus and Kevin De Bruyne also return.
Benjamin Mendy makes a welcome return on the bench, alongside teenage defender Eric Garcia
TV GUIDE: Where to see Shakhtar v City
Blues look for solid start
City lost the opening group stage clash with Lyon and were immediately on the back foot.
The Blues will not only want to get off to a flyer but erase the weekend loss against the Canaries and get back on track.
