The academy duo come into a much-changed side, with Pep Guardiola making eight alterations to the team that beat Sheffield United on Tuesday.
Claudio Bravo replaces Ederson in goal, continuing Guardiola’s policy of selecting the Chilean for domestic cup competitions.
And Joao Cancelo, Angelino, Ilkay Gundogan, Bernardo Silva and David Silva also come back into the starting XI.
Only Gabriel Jesus, Riyad Mahrez and Nicolas Otamendi remain from the victory at Bramall Lane.
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City team
XI: Bravo, Cancelo, Garcia, Otamendi, Angelino, Gundogan, Foden, Silva, Bernardo, Mahrez, Jesus
SUBS: Ederson, Stones, Sterling, Aguero, Zinchenko, Rodrigo, De Bruyne
Fulham team
XI: Rodak, Hector, Johansen, Ream, Decordova-Reid, Kongolo, Cavaleiro, Christie, Bryan, Onomah, Sessegnon
SUBS: Bettinelli, Odoi, McDonald, Cairney, Jasper, Stansfield, De La Torre
City tactics
It looks like 4-3-3 for City this afternoon, with Bravo protected by a back four of Cancelo, Garcia, Otamendi and Zinchenko.
Gundogan will sit just in front of the back four, with Silva and Foden pulling the strings ahead of the German.
Bernardo and Mahrez will play out wide in support of Jesus, who will operate centrally.
Gaining control of possession early on, as always, will be priority No. 1 for City, who will look to play on the front foot and take the game to Fulham in an aggressive manner.
The West Londoners may be underdogs – but they are a side who like to open up and play attacking football. If they stick to their principles, it should make for an entertaining game.
Match stats
Head-to-head
Manchester City last faced Fulham in the FA Cup in 1914 - a 2-0 home win at Hyde Road.
City have won the past eight meetings in all competitions, by an aggregate score of 23-3.
They are undefeated in 14 matches against Fulham (W11, D3).
Fulham’s past three wins against City have all come away from home in the Premier League, in April 2009, April 2008 and April 2006.
Manchester City
Manchester City have won 10 of their past 12 games in all competitions. Their only defeat during that run came at Wolves in the Premier League on 27 December.
City have lost only once in 12 home games (W9, D2).
They have won all five FA Cup home matches under Pep Guardiola by an aggregate score of 25-3.
Since joining City in 2011-12, Sergio Aguero has scored a competition-high 19 FA Cup goals.
Fulham
Fulham have lost just once in eight matches in all competitions.
However, they have won only once in five away games (D2, L2).
Fulham have not conceded a goal since the third-round win against Aston Villa, keeping three clean sheets.
The Cottagers last made the fifth round in 2011, going on to lose 1-0 at home to in an all-Premier League clash.
