City go into the game top of the Premier League, eight points clear of second-placed Manchester United, following a hard-fought 2-1 triumph at Huddersfield.
Southampton sit in tenth position and head into the clash on the back of a 4-1 thrashing of Everton.
When and where
The game will be played at the Etihad Stadium on Wednesday 29 November, kick-off at 8pm (GMT).
The game will not be shown live in the UK. We’ll compile a list of full global TV listings shortly.
Alternatively you can download our City Matchday app for Android | City Matchday app for iOs to follow the game live.
Team news
City remain without long-term absentee Benjamin Mendy, who is still recovering from anterior cruciate ligament damage, while John Stones is sidelined with a hamstring injury.
For Southampton, Matt Targett is a slight doubt, having suffered a knock.
Referee
Paul Tierney will take charge of the game with Adrian Holmes and Mick McDonough as his assistants. Bobby Madley will be the fourth official.
The Last Time
The two sides last met in April at St Mary’s Stadium, with City running out 3-0 victors thanks to goals from Vincent Kompany, Leroy Sane and Sergio Aguero.
The Saints’ last trip to the Etihad Stadium heralded a 1-1 draw as Kelechi Iheanacho cancelled out Nathan Redmond’s opener.
