The Bosnia striker, who couldn’t buy a Premier League goal last season, snapped up a perfect hat-trick then added an injury-time stunner to emphasise his own potency and that of the buoyant Blues.
Samir Nasri conjured an impressive enough midfield debut on his instant return to north London, but his performance - and a good few others - was totally overshadowed by Dzeko’s irresistible display.
Paul Whitehouse was among the stunned crowd, and as his comic creation Ron Manager would doubtless have said of City’s biggest-ever win on Tottenham soil: “Marvellous, isn’t it?”
Aguero added to Dzeko’s first City hat-trick - right foot, left foot, and header - before the big man put the icing on the cake with a spectacular fourth in the dying seconds, taking him to six goals in three games since Wembley.
Shattered Spurs belatedly hit back through defender Kaboul, but it barely made a dent
Mancini’s threat that City would carry far more attacking intent this season - made before Nasri was finally prised away from Arsenal - could not have been underlined in more dramatic fashion.
The alarm bells should have gone off for Harry Redknapp’s men when they found former derby foe Nasri surprisingly lining up alongside David Silva and Sergio Aguero behind Dzeko.
Few expected the Frenchman to start so soon. Not only did he do so, he fitted in so snugly that City’s consistent passing and movement was eventually too much for the home side to handle.
Indeed, Nasri was instrumental in cresating both the goals with which Dzeko put the Blues in control before half time, after Gareth Bale had missed the best chance of the game so far.
Minutes later, Nasri combined with Aguero in a neat one-two on the left flank that allowed the former to ping in the cross that Dzeko stretched to steer beyond veteran Brad Friedel.
If that was stinging notice to Spurs that City have taken a huge step on from last season’s Joe Hart-inspired goalless draw, then Dzeko’s second was a sign he is back to his sharpest.
Five minutes before half time, with Peter Crouch having just failed to equalise with a brilliant flying header that kissed the outside of a post, Dzeko produced a wonderful header of his own.
Despite moving away from goal, and with Kaboul in close attendance, the Bosnian ace made strong contact with Nasri’s cross and directed a perfectly-placed header to leave Friedel stranded.
Mancini might have been concerned at his team’s failure to satisfy the referee - Gareth Barry and Pablo Zabaleta picked up yellows for fouls and Yaya Toure was booked for dissent.
But this was a performance that could hardly fail to please the manager, and against a team that have, until now, been among their fiercest rivals in challenging the status quo.
The subdued atmosphere in the home crowd was further increased early in the second half when Toure fired in a low cross that left Dzeko with the easiest finish he will enjoy for some time.
Aguero reminded Spurs of his own threat by bamboozling skipper Michael Dawson before hammering an angled fourth goal before Kaboul moved up to exploit City’s odd vulnerability at corners.
Dzeko, inevitably, had the last word, a first-time shot from range that Friedel could only admire.
