The match gets underway at 12:30 (UK) on Saturday 6 November at Old Trafford, with a vital three points up for grabs as well as local bragging rights.
Victory for City would see Pep Guardiola’s men go into the international break on a high, and potentially push us back to within two points of the Premier League summit.
Our opponents on the other hand will be aiming to build on a first league win in four matches last time out against Tottenham Hotspur.
Everything points towards a thrilling clash at Old Trafford, but how well do you remember our previous encounters with the Reds?
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Do you know who City’s record goalscorers are against Manchester United? Who grabbed the opener in our famous 6-1 win in 2011? And who was in the United dugout when Pep Guardiola claimed a Derby win at the first time of asking back in 2016?
Cityzens can take the quiz below to find out. Good luck!