Pep Guardiola’s men travel to the Tottenham Hotspur Stadium on Friday 26 January, with kick-off set for 20:00 (UK).
FA Cup holders City will progress to the last 16 with a victory, but are yet to score at Spurs’ new home in five visits.
The fixture is available to watch live in the United Kingdom on ITV with further broadcast information available via livesoccertv.com at the foot of this page.
As always, the official Man City app will also keep you across all the action from North London in one handy place.
From 18:00 (UK) and continuing across the evening, our Matchday Centre will provide detailed stats, analysis and text commentary, including plenty of detailed reaction.
Matchday Live will have expert insight via our special studio guests who will provide plenty of entertaining anecdotes along the way on all our digital platforms from around one hour prior to kick-off.
Once the action does get under way, Alistair Mann will provide live audio commentary along with a guest commentator, while those with push notifications turned on will also be alerted to the key moments from the game.
The comprehensive coverage continues after the final whistle, with a detailed match report and plenty of reaction from Pep Guardiola and players available soon after full-time.
A full highlights package of the game will also follow.
Find out how you can tune in to Spurs v City via the listings below…