And the tie will be broadcast live in the United Kingdom on TNT Sports 1, HBO Max, BBC One and BBC iPlayer.
Pep Guardiola’s side booked our place in Wembley’s last-four following a fantastic 4-0 victory over Liverpool at the quarter-final stage.
An Erling Haaland hat-trick - his 12th for the Club - and Antoine Semenyo’s sublime chip helped us to the fine result at the Etihad.
That success over Arne Slot’s side followed wins over Exeter, Salford and Newcastle as we pursue the major trophy for the eighth time in our illustrious history.
The Saints, meanwhile, booked their place in the semi-final following a memorable 2-1 victory over Arsenal in the last-eight after beating Doncaster, Leicester and Fulham.
Tonda Eckert’s team have one FA Cup to their name when beating Manchester United in the 1976 showpiece at Wembley.
The other semi-final, which will see Chelsea take on Leeds United, will be played on Sunday 26 April, with kick-off at Wembley set for 15:00 (UK).
Ticket details for our 17:15 (UK) semi-final clash with Southampton at Wembley on Saturday 25 April will be announced in due course.
Stay close to mancity.com and the Official Man City App for updates and all future fixture details.
