UK viewers will be able to watch the match on TNT Sports and discovery+, with a full global broadcast schedule to be confirmed closer to the time.
It will be the fifth meeting between the sides this season, with City winning both legs of the Carabao Cup semi-final after a defeat at St James’ Park in the Premier League.
The return top-flight fixture will be played at the Etihad Stadium this Saturday.
City reached the fifth round of the FA Cup with victories over Exeter City and Salford City, while Newcastle are in the last-16 thanks to defeats of Bournemouth and Aston Villa.
After three successive finals, we’re aiming to return to Wembley again this spring.
We’ve won the historic competition seven times in total, with Pep Guardiola leading us to two of those triumphs.
Keep your eyes peeled on mancity.com and our official app for ticket information.
Full FA Cup fifth round schedule
Wolves v Liverpool, 20:00, Friday 6 March, TNT Sports and BBC
Mansfield Town v Arsenal, 12:15, Saturday 7 March, TNT Sports
Wrexham v Chelsea, 17:45, Saturday 7 March, TNT Sports and BBC
Newcastle v City, 20:00, Saturday 7 March, TNT Sports
Fulham v Southampton, 12:00, Sunday 8 March, TNT Sports
Port Vale or Bristol City v Sunderland, 13:30, Sunday 8 March, TNT Sports
Leeds v Norwich, 16:30, Sunday 8 March, TNT Sports
West Ham v Brentford, 19:30, Monday 9 March, TNT Sports