Natalie Pike will present this edition of Matchday Live while Shaun Wright-Phillips and FG are pitchside at Kenilworth Road to sample the FA Cup atmosphere.
Once the game kicks off at 20:00 (UK), Alistair Mann and Michael Brown will talk you through proceedings.
That’s all running alongside dedicated text commentary from our club journalists throughout the evening.
As always, it’s all free and available on mancity.com and our official app this Tuesday 27 February.
Pep Guardiola‘s side are looking to defend the trophy we won last June, beating Manchester United at Wembley thanks to two Ilkay Gundogan volleys.
We travel to Luton after victories over Huddersfield Town and Tottenham Hotspur so far in this year’s competition.
Luton have reached the last-16 thanks to wins against Bolton Wanderers and Everton.
The two sides have already met once in the league this season, with goals from Bernardo Silva and Jack Grealish seeing us come from behind after Elijah Adebayo had headed the Hatters in front.
We will host Rob Edwards’ team in the Premier League in April.
Before then, it’s all eyes on this FA Cup clash.
Join us on mancity.com and our official app from 18:00 (UK) for text build up before the studio show gets going at 18:50.
It’s the perfect accompaniment to your Manchester City match day!