City go into the final game of the Premier League season with a third title in three years already wrapped up.
However, with FA Cup and Champions League finals to come in the next two weeks, Guardiola is keen to manage his squad.
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After sealing the trophy last Saturday following Nottingham Forest’s victory over Arsenal, the boss made nine changes for Sunday’s meeting with Chelsea.
He then made another six switches for Wednesday night’s draw at Brighton and Hove Albion.
Asked about whether he knows who he will have available on Sunday, Guardiola said: “No. Today no, but some [players are] half and half.
“It’s getting better. Some of them. We’ll see tomorrow, we’re training tomorrow afternoon and decide how they feel. We need to keep our rhythm before the finals.”
While the final game of the Premier League season will not affect City’s league position, Guardiola is still relishing the prospect of going up against Thomas Frank’s side.
The Bees are ninth in the Premier League and have an outside chance of Europa Conference League qualification should they win and results elsewhere go their way.
Although the finals loom large on the horizon, Guardiola is focused on putting in a strong performance in west London.
“First it’s Brentford, they’ve only lost once at home. Incredible season,” said Guardiola.
“They are so difficult to play against.
“After that we have time to disconnect. To not see each other two days and have to prepare for United first and then Inter.”
Brentford v City: App coverage
We will have full coverage of Sunday’s match right here on the official Man City app.
Our Matchday Centre will be available from 14:30 (UK), providing you with live text updates before, during and after the game.
Our Matchday Live programme will begin shortly before team news arrives at 15:30 (UK).
Host Natalie Pike will welcome City favourites Paul Dickov, Esme Morgan and Nedum Onuoha into the studio to provide you with a City-centric view on the events at the Gtech Community Stadium.
During the game meanwhile, Alistair Mann and Michael Brown will guide you through proceedings with our radio commentary.
Extended highlights will be available at midnight (UK) on Sunday and CITY+ subscribers can watch a full 90-minute replay from midnight.
Don’t forget, the best way to follow Manchester City is by downloading our official app!
And when you do, turn on notifications to get alerted as to when our Matchday Live show starts.
Download on your mobile phone or tablet via Apple’s App Store or Google Play store, or, if you already have the app, then simply visit the stores and update.