Pep Guardiola’s side go into the game with a perfect record in Group G, knowing a victory would guarantee top spot with a game to spare.
The European champions have scored 12 and conceded just three in our four matches so far.
RB Leipzig are second in the group, with nine points from their four games.
The two teams met at the start of October, with goals from Phil Foden, Julian Alvarez and Jeremy Doku winning the day for City in Germany.
Fans in the UK can watch the match across TNT Sports and discovery+, with the global options available below.
Alternatively, you can keep up to date with everything that happens before, during and after the match via our Matchday Centre on mancity.com and on our official app, as well as the best of the action on Twitter: @ManCity.
Once the game has concluded, there will also be a detailed match report, highlights and full-match replay, available via CITY+.
Our Matchday Live show will begin around one hour before kick-off, as the team news comes in.
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Shaun Goater, Steve Howey and our Under-18s coach Ben Wilkinson will join host Cel Spellman in the studio to provide City-centric analysis throughout the day.
During the game, you can also listen to our live audio commentary offering with Alistair Mann on hand to guide you through proceedings while out text commentary continues.
View the global TV listings for City v RB Leipzig below, courtesy of livesoccertv.com.