Pep Guardiola‘s men will attempt to do exactly that, with the holders beginning their quest against League One side Wycombe Wanderers.
The game kicks off at 7.45pm (UK) on Tuesday 21 September and you can you can follow minute-by-minute updates on ManCity.com and the Man City App through our Matchday Centre, or over on Twitter: @ManCity.
Highlights will be available on the official website from 1am on Wednesday the Full Match Replay from midnight.
The game will not be screened live in the UK, but you can check out our global TV listings to see where in the world you can watch the game.
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You can also tune in to our Matchday Live show, which begins one hour before kick-off at 6.45pm (UK).
Matchday Live is available on all our digital platforms, including our Matchday Centre, and provides half-time and full-time analysis in addition to 60 minutes of pre-match build-up.
Check out how you can watch the game via the TV listings below, courtesy of livesoccertv.com
| Angola |
SuperSport Football Plus ROA, DStv Now |
| Anguilla |
ESPNPlay Caribbean |
| Antigua and Barbuda |
ESPNPlay Caribbean |
| Aruba |
ESPNPlay Caribbean |
| Australia |
beIN Sports Connect |
| Austria |
DAZN |
| Barbados |
ESPNPlay Caribbean |
| Belize |
ESPNPlay Caribbean |
| Benin |
SuperSport Football Plus ROA |
| Botswana |
DStv Now, SuperSport Football Plus ROA |
| Brazil |
ESPN Brasil, Watch ESPN Brasil, NOW NET e Claro, GUIGO |
| British Virgin Islands |
ESPNPlay Caribbean |
| Burkina Faso |
DStv Now, SuperSport Football Plus ROA |
| Burundi |
SuperSport Football Plus ROA, DStv Now |
| Cameroon |
SuperSport Football Plus ROA, DStv Now |
| Cape Verde |
SuperSport Football Plus ROA, DStv Now |
| Cayman Islands |
ESPNPlay Caribbean |
| Central African Republic |
SuperSport Football Plus ROA |
| Chad |
DStv Now, SuperSport Football Plus ROA |
| Comoros |
SuperSport Football Plus ROA |
| Congo |
DStv Now, SuperSport Football Plus ROA |
| Costa Rica |
Sky HD |
| Cote D’Ivoire |
SuperSport Football Plus ROA, DStv Now |
| Cuba |
ESPNPlay Caribbean |
| Cyprus |
Cytavision on the Go, Cytavision Sports 5 |
| Denmark |
TV3 Sport, Viaplay Denmark |
| Djibouti |
DStv Now |
| Dominica |
ESPNPlay Caribbean |
| Dominican Republic |
Sky HD, ESPNPlay Caribbean |
| El Salvador |
Sky HD |
| Equatorial Guinea |
DStv Now, SuperSport Football Plus ROA |
| Eritrea |
SuperSport Football Plus ROA, DStv Now |
| Ethiopia |
DStv Now |
| France |
beIN Sports MAX 7, beIN SPORTS CONNECT, Free |
| Gabon |
DStv Now, SuperSport Football Plus ROA |
| Gambia |
DStv Now, SuperSport Football Plus ROA |
| Germany |
DAZN |
| Ghana |
SuperSport Football Plus ROA, DStv Now |
| Grenada |
ESPNPlay Caribbean |
| Guadeloupe |
ESPNPlay Caribbean |
| Guatemala |
Sky HD |
| Guinea |
DStv Now, SuperSport Football Plus ROA |
| Guinea-Bissau |
SuperSport Football Plus ROA, DStv Now |
| Haiti |
ESPNPlay Caribbean |
| Honduras |
Sky HD, ESPNPlay Caribbean |
| Iceland |
Stöð 2 Sport 3 |
| Indonesia |
Mola TV, Mola TV App, mola.tv |
| Israel |
Sport 1 |
| Italy |
DAZN |
| Jamaica |
ESPNPlay Caribbean |
| Kenya |
DStv Now, SuperSport Football Plus ROA |
| Latvia |
Viaplay Latvia |
| Lesotho |
DStv Now |
| Liberia |
DStv Now, SuperSport Football Plus ROA |
| Madagascar |
SuperSport Football Plus ROA, DStv Now |
| Malawi |
SuperSport Football Plus ROA, DStv Now |
| Mali |
DStv Now, SuperSport Football Plus ROA |
| Martinique |
ESPNPlay Caribbean |
| Mauritania |
DStv Now |
| Mauritius |
DStv Now, SuperSport Football Plus ROA |
| Mexico |
Blue To Go Video Everywhere, Sky HD |
| Montserrat |
ESPNPlay Caribbean |
| Mozambique |
SuperSport Football Plus ROA, DStv Now |
| Namibia |
SuperSport Football Plus ROA, DStv Now |
| Nicaragua |
Sky HD |
| Niger |
DStv Now, SuperSport Football Plus ROA |
| Nigeria |
DStv Now, SuperSport PSL |
| Norway |
V Sport+, Viaplay Norway |
| Panama |
Sky HD |
| Portugal |
Sport TV Multiscreen, Sport TV3 |
| Puerto Rico |
ESPNPlay Caribbean |
| Rwanda |
SuperSport Football Plus ROA |
| Saint Barthelemy |
ESPNPlay Caribbean |
| Saint Kitts and Nevis |
ESPNPlay Caribbean |
| Saint Lucia |
ESPNPlay Caribbean |
| Saint Martin |
ESPNPlay Caribbean |
| Saint Vincent and the Grenadines |
ESPNPlay Caribbean |
| Sao Tome And Principe |
SuperSport Football Plus ROA |
| Senegal |
SuperSport Football Plus ROA, DStv Now |
| Seychelles |
SuperSport Football Plus ROA, DStv Now |
| Sierra Leone |
SuperSport Football Plus ROA, DStv Now |
| South Africa |
SuperSport PSL, DStv App |
| South Sudan |
SuperSport Football Plus ROA, DStv Now |
| Spain |
DAZN, DAZN 1, Movistar+ |
| Sudan |
DStv Now |
| Swaziland |
DStv Now, SuperSport Football Plus ROA |
| Sweden |
Viaplay Sweden, V Sport Extra |
| Switzerland |
DAZN |
| Tanzania |
SuperSport Football Plus ROA, DStv Now |
| Timor-Leste |
mola.tv, Mola TV |
| Togo |
DStv Now, SuperSport Football Plus ROA |
| Trinidad and Tobago |
ESPNPlay Caribbean |
| U.S. Virgin Islands |
ESPNPlay Caribbean |
| Uganda |
SuperSport Football Plus ROA, DStv Now |
| United States |
ESPN+ |
| Zambia |
SuperSport Football Plus ROA |
| Zimbabwe |
SuperSport Football Plus ROA, DStv Now |
