Gareth Taylor’s side will lock horns with the Gunners at Meadow Park on Sunday 11 February, with kick-off scheduled for 12:30 (UK).
Our fixture with Jonas Eidevall’s side will be broadcast live on BBC Two and BBC iPlayer in the United Kingdom.
City reached this stage of the prestigious competition with a comprehensive 4-0 victory over Durham in the fourth round, while the Londoners secured passage with a 5-1 win over Watford.
And the tie will represent the second time the Barclays Women’s Super League title rivals have met this term.
In November’s league clash, we suffered a narrow 2-1 defeat in the capital when Stina Blackstenius’ late goal broke the visitors’ hearts after Chloe Kelly had equalised after Steph Catley’s opener.
Stay close to mancity.com and our official app for ticket details and all future fixture announcements.