It’s a repeat of last season’s Round of 16 tie which ended in a 4-1 aggregate win for the La Liga side.
FC Barcelona topped Group F with 15 points from their six games and are currently placed second in La Liga, four points behind Real Madrid.
Luis Enrique’s men reached the quarter-finals of last year’s competition where they were knocked out by eventual runners-up, Atletico.
Manuel Pellegrini’s men will play the first leg at the Etihad Stadium on 24 February and the away leg at the Camp Nou on 18 March.
Ticket information will be released in due course.
City v Crystal Palace
It’s City’s last game at the Etihad Stadium before Christmas and you can be here to find out if the champions can keep up the pressure on Premier League leaders, Chelsea.
Tickets are still available for Saturday’s lunchtime kick-off against Crystal Palace online at www.mcfc.co.uk/tickets, by telephone on +44 161 444 1894 (option 1, option 1, option 2)* and to personal callers at the Ticket Office above the City Store at the Etihad Stadium.
Book now to avoid disappointment!