Speaking in his pre-match press conference, the Blues boss admitted a strong first-leg advantage provides the perfect chance to make changes, but explained Vincent Kompany, Ilkay Gundogan and Bacary Sagna are not yet in contention.
“In terms of long-term injuries, Vincent Kompany and Ilkay Gundogan have little problems,” he said. “We have ten days to work with them and improve their physical conditions.
“Hopefully, when we come back from the international break, they will be a full part of our training sessions.
“Bacary Sagna is not available. Against West Ham is it not possible for him to play. Maybe at Old Trafford.
“Joe Hart and Yaya Toure have a chance to play tomorrow.
“We had 28 players in the training session. It’s difficult for me to leave players who deserve to play out. We’ve played tough games in the last week. I will make some rotations with the players.”
Despite a 5-0 advantage from the away clash, Guardiola also warned against complacency, insisting it is not acceptable in football.
He added: “I have lot of respect for the opponents and I know what can happen in football.
“Everybody knows nothing is done until it is done. We are so happy with 5-0 but we have to take the opponent seriously and try to win the game.
“Look at the Champions League final with Liverpool and AC Milan - 3-0 at half-time and that was a Milan with many experienced players.
“We have a huge advantage but we will not play tomorrow thinking it’s done.
“Results help us to be more calm. We have to try to play as good as possible to achieve the result. I was pretty sure we would be able to do that.”
When asked of his thoughts on his side’s impressive start to life under his leadership and new style, he replied: “Most of the players get it quickly. We are a little bit surprised how quickly it has happened.
“We have to improve a lot but in the short time we have been together, we have made very good things.”