In his final game at the helm at the Etihad Stadium, the Chilean brings Eliaquim Mangala back into the team at the expense of the injured Vincent Kompany and starts Kelechi Iheanacho ahead of Yaya Toure.
The lethal Nigerian 19-year old is selected for successive Premier League games for the first time in his career after he netted a brace last time out away at Southampton.
Iheanacho will partner Sergio Aguero in attack, while Kevin De Bruyne and Jesus Navas will provide the width on either side.
Elsewhere, it’s an all-Brazilian central midfield and all-French full-back combination with Bacary Sagna and Gael Clichy on either side of Mangala and Nicolas Otamendi.
On the bench, Pellegrini rewards 19-year old left-back Angelino with a place in the matchday squad for the first time since the FA Cup match at Aston Villa on 30 January.
Angelino is joined on the bench by plenty of firepower in the shape of Wilfried Bony, Raheem Sterling and Yaya Toure.
City XI: Hart, Sagna, Otamendi, Mangala, Clichy, Fernando, Fernandinho, Navas, De Bruyne, Iheanacho, Aguero
Subs: Caballero, Angelino, Demichelis, Delph, Toure, Sterling, Bony
Arsene Wenger names an attacking XI for the game but is without chief architect Mesut Ozil who misses out with a slight hip injury.
Gabriel comes in for the injured Per Mertesacker and Olivier Giroud starts up front, with a supporting cast of Alex Iwobi, Alexis Sanchez, Danny Welbeck and Aaron Ramsey.
Jack Wilshere, Theo Walcott and Santi Cazorla are all on the bench.
Arsenal XI: Cech, Bellerin, Gabriel, Koscielny, Monreal, Elneny, Ramsey, Welbeck, Iwobi, Sanchez, Giroud
