As ever, the destinations are far and wide with Pep Guardiola hoping none of the squad pick up any knocks while away with their country.
Starting close to home and Raheem Sterling and John Stones should both feature in England’s back-to-back Wembley matches against Scotland and Spain.
David Silva and Nolito should face their City team-mates in the Wembley friendly a week on Wednesday, though both should feature for Spain against Macedonia this weekend.
Belgian pair Kevin De Bruyne and Vincent Kompany will hope to appear for the Red Devils who face Holland and Estonia, while Aleksandar Kolarov’s Serbia face Wales on Saturday and Ukraine next Tuesday.
Ilkay Gundogan’s Germany face San Marino and Italy while Leroy Sane will play for the Under-21s against Turkey and Poland.
Kelechi Iheanacho’s Nigeria take on Algeria this Saturday lunchtime but it is perhaps the South American World Cup Qualifiers that will capture the imagination with Brazil hosting Argentina on Thursday evening.
Fernandinho and soon-to-be City striker Gabriel Jesus should start for the hosts, with Pablo Zabaleta, Nicolas Otamendi and Sergio Aguero lining up for the Albacete.
Brazil will also travel to Peru next Tuesday and Argentina will host Marlos Moreno’s Colombia.
Claudio Bravo should once again skipper Chile as they take on Colombia and Uruguay.
Angus Gunn is also on international duty with England Under-21s.
