The Manchester City midfielder, making his 110th appearance for his country, finished superbly through the legs of Israel goalkeeper Ofir Marciano after Jordi Alba’s brilliant pass.
He now has 29 goals for Spain, putting him level with Real Madrid legend Fernando Hierro and nine behind third-placed Fernando Torres.
Further goals from Vitolo, Diego Costa and Isco made the win a comfortable one for Spain, with Lior Refaelov getting one back for the visitors.
Spain stay top of Group G in their World Cup qualifying campaign, ahead of Italy on goal difference.
Teams:
Spain (4-3-3): De Gea; Carvajal, Ramos, Pique, Alba; Iniesta (Isco 70’), Busquets, Thiago (Koke 63’); Silva, Vitolo (Iago Aspas 84’), Costa.
Subs: Kepa, Martinez, Azpilicueta, Morata, Herrera, Natcho, Deulofeu, Rico, Pedro
Israel (4-2-3-1): Marciano; Dasa, Tibi (Tawatha 19’), Tzedek, Gershon; Natcho, Cohen; Ben Haim Hemed 64’), Einbinder (Keltjens 60’), Rafaelov; Zahavi.
Subs: Kleyman, Micha, Bitton, Ohana, Sahar, Harush, Elo, Sechter, Yeini
