When and where
The game takes place at the VELTINS-Arena on Wednesday 20 February, with kick-off at 8pm GMT.
It will be shown live on BT Sport for UK viewers - and you can also keep up-to-date with all the action via our Matchday Centre or our Twitter: @ManCity.
You can find out how to tune into the game - wherever you are in the world - via our global TV listings.
Team news
Schalke
Alessandro Schöpf, Breel Embolo, Benjamin Stambouli are all out for Schalke.
City
Vincent Kompany is in the 20-man squad bound for Schalke.
However, Benjamin Mendy, Fabian Delph, John Stones (groin) and Gabriel Jesus (hamstring) are not fit to travel.
“John has a groin problem,” Guardiola said. “Jesus has a hamstring problem,” he said.
“I don’t think it is a big, big problem but enough for them not to come.”
Last time
City secured a 2-0 victory away at Schalke in the 2008 UEFA Cup. Benjani and Stephen Ireland scored the goals that night.
City also beat Schalke 5-2 on aggregate en route to winning the 1970 European Cup Winners’ Cup.
Domenico Tedesco preview
“We are the clear underdogs in the game, that much is obvious.
“But we deserve to be here because we advanced deservedly from a group of good teams.
“We have to have a perfect day if we are to get anything out of the game. We owe it to us and to Schalke.”
Pep preview
“I believe the team can do better things than the first season.
“We know each other much better. But this competition is special. The teams are good.
“You have to control your emotions. You have to suffer and survive the bad moments. But we are confident.
“We have many dreams in our head. It’s important to score goals - the minimum one goal.
“You can’t go through if you are not yourself. If you don’t do your best performance.
“If you want to dream, go through to the last stages, every single second you have to be incredible: impose your game.
“To be ourselves, that is what i want to feel”
Match officials
Referee: Carlos Del Cerro (ESP)
Assistant referees: Juan Yuste (ESP), Roberto Alonso (ESP)
Video Assistant Referee: Alejandro Hernandez (ESP)
Assistant Video Assistant Referee: Juan Martinez Munuera (ESP)
Fourth official: José María Sanchez Martinez (ESP)
