The pair both picked up knocks during Wednesday’s Champions League quarter-final second leg tie away to Atletico Madrid.
But, speaking at Friday’s pre-match press conference ahead of the Wembley assignment against Liverpool, the City boss said the duo would be assessed tomorrow to determine whether they would be available for selection.
And, asked whether Zack Steffen would start in goal, the boss added that he would make a decision on his line-up after monitoring the fitness of all the squad following a gruelling past few games.
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“They (Walker and De Bruyne) didn’t train today. We will see tomorrow. Apparently, it will be so close after what happened on Wednesday but we will see,” Guardiola said.
“Kyle had a big twist. He is getting better. We will see in the next hours, the next days. In football these kinds of things happen. We will adapt, adjust and go from here.
“Kevin had stitches after he had contact – it’s not a muscular injury.
“I am going to think about it (Zack Steffen starting). I still have to speak tonight with the doctors and physios about the condition of many players.
“Tonight, tomorrow morning I will decide but, of course, in the FA Cup I normally play Zack and that is an option tomorrow.”
Saturday’s game comes in the midst of an intense, demanding schedule for City who have played Atletico Madrid twice and Liverpool already in the past 11 days.
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But the boss said he and the players would make the most of the situation with City delighted to still be in the hunt for three major trophies and hungry for success.
“It is what it is. It would look like I am looking for an excuse. I would prefer more days with more than 16 players that we have right now,” the City boss added.
“I have said many times about the schedule, but it is no sense because it is not going to change.
“We are incredibly happy to be here. We are going to try and perform well against Liverpool which is not easy. We will try to do our game.
“Always I have the feeling we arrive one and half months to the end of the season and we are in two semi-finals in the FA Cup and Champions League.
“We are top of the Premier League and in two semis. It is so great.”
