Joao Cancelo, Riyad Mahrez and Bernardo are all recalled, with Phil Foden, Ilkay Gundogan and Oleks Zinchenko making way.
Nathan Ake returns to the squad and is on the bench.
Line-ups:
City: Ederson, Walker, Cancelo,. Dias, Laporte,. Rodrigo, De Bruyne (c), Bernardo, Torres, Sterling, Mahrez
Subs: Trafford, Stones, Ake, Gundogan, Zinchenko, Foden, Garcia
Sheffield United: Ramsdale, Basham, Egan, Stevens, Baldock, Berge, Ampadu, Osborn, Lowe, Brewster, McBurnie
Subs: Lundstram, Sharp, Burke, Norwood, McGoldrick, Robinson, Verrips
Probable tactics and formation: 4-3-3
Ruben Dias and Aymeric Laporte get another opportunity to further develop their partnership this afternoon, flanked by Kyle Walker and Joao Cancelo.
Rodrigo will take up his usually anchoring role behind Kevin De Bruyne and Bernardo in midfield.
Up front, Ferran Torres, Raheem Sterling and Riyad Mahrez will no doubt keep the attack fluid and chop and change positions to keep the hosts on their toes.
Blades sharpening up?
It will be interesting to see how Sheffield United approach this game.
The Blades are desperate to get their season up and running after one draw and five defeats has left them second bottom in the Premier League.
Chris Wilder’s side were very unlucky not to take anything from their recent games against Arsenal and Liverpool and are clearly performing much better than their league position suggests.
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With 13 shots on target at Anfield, United were unlucky not to increase their early 1-0 lead and were denied a couple of penalty shouts, too.
With wet and gusty conditions expected at Bramall Lane, the hosts will set out to make it an uncomfortable afternoon for City, so expect plenty of energy, no-nonsense tackling, and a focus on getting the ball out of defence quickly.
It could be a challenging afternoon for our defenders.
Stats and milestones
Kyle Walker, who began his career at Sheffield United, will make his 100th Premier League appearance for City this afternoon.
The Blades have never beaten City in the Premier League in eight attempts, the most they’ve faced any side in the division without winning (D3, L5), scoring only one goal in those eight games.
City are looking to win four consecutive league games against Sheffield United for the first time since March 1930.
The Blades are winless in six league meetings since a 1-0 triumph in the second tier in January 2000.
United have earned a solitary point from their past nine Premier League fixtures since beating Chelsea in July.
Manager Chris Wilder has won 99 of his 202 matches in charge of the club in all competitions.
Since the beginning of last season, City are winless in all seven Premier League away matches when they conceded the opening goal (D1, L6).
No side has won more English top-flight fixtures on Halloween than Manchester City’s tally of 10 - level with Arsenal.
Riyad Mahrez has been directly involved in 99 goals in 203 Premier League appearances, scoring 58 and providing 41 assists.
