John Stones, Kyle Walker and Ruben Dias will miss the remaining weeks of the season with injury, though there are no fresh concerns ahead of the game at Molineux.
“Nothing changed after the game against Newcastle,” said Guardiola at his Friday press conference.
“We are who we are and are going to last three games with the players we have and go for it.
“We have problems in other departments, but the others are going to solve it.”
The City boss is expecting one of the hardest tests of the campaign against Wolves who held Chelsea 2-2 at the weekend.
The Black Country outfit still have a chance of securing a Europa Conference spot and Guardiola believes his players will need to be at their very best to secure three vital points.
“It’s not about the last result,” he said.
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“They were really good at Stamford Bridge but always Wolves since being promoted, they are one of the toughest opponents we face.
“They are always dangerous for the transition from Dendoncker, the quality of Moutinho, the personality and competitiveness they have.
“The back five that they play, (it is one of) the toughest away games we have in the season - and we have right now - but at the same time we know how important it is.
“Hopefully we recover well from last week and can do a good game.
“This is the most important thing in our heads right now.”
