Vincent Kompany is fully fit and ready for selection after taking part in training throughout the week, while Raheem Sterling, rested for the draw with Stoke City on Wednesday, is also available.
Only long-term injury victims Ilkay Gundogan and Gabriel Jesus will miss the game at the Riverside Stadium as City look to book a date at Wembley in next month’s semi-final.
And Guardiola is set to field a strong side at the Riverside.
“I trust in all the players. Of course I trust more in (certain) ones because I normally play more players than the other ones, but what we decided against Stoke City was to win the game, not just thinking about Middlesbrough,” said Guardiola.
“Of course it’s a final, away game, we would prefer to play just one game in the cup at home with our fans, it was not possible this year. It’s a final, you have to put the best squad as possible.
“Kompany is already back,” Guardiola added. “He trained three days, four days with us. He has already come back in the training sessions with the team.”
Guardiola has twice experienced huge showpiece matches at Wembley and a win over Middlesbrough on Saturday would see him return for a third time next month for a showpiece FA Cup semi-final.
DREAM TEAM: Pep Guardiola was part of the Barcelona team that won the European Cup in 1992
He was part of the Barcelona side that beat Sampdoria to win the European Cup in 1992 at the old Wembley - and he returned to the new stadium as a manager as his Barcelona side defeated Manchester United to win the Champions League in 2011.
Guardiola says he wants to go there again, this time with his improving City side.
“As a football player, I won my first Champions League at the old Wembley, and then as a manager won my second Champions League there. Of course, Wembley is special for me, definitely.
“When I was a kid seeing the English football playing at Wembley – all competitions, important games – there is tradition there when the two managers walk out. I love that. It’s a traditional stadium.
“Of course I will be pleased, not just to go back and remember what we have done, but because playing semi-final there will be nice. And after we can play the final.”
