The Blues will face 2010/11 champions FC Porto, with the away leg first in mid-February on a date to be confirmed.
City exited the Champions League despite accruing 10 points in a difficult group from which Bayern Munich and Napoli proceeded, and they now face a side with considerable European pedigree.
“Porto is probably the toughest game we could have,” Roberto told mcfc.co.uk. “Manchester City against Porto feels like a Champions League game. I have come up against them as a player before and also a manager, they are a very good team and a very strong club in Europe.
“They are used to playing in Europe, in a great stadium. Not too many years ago they won the Champions League and also won the Europa League last year so they are a strong team.
“It will be a hard match for us. When I looked at the teams we could face I thought Porto would be the toughest. We know this game will be difficult, but also it will be difficult for them. It is a good game for the fans, a big team coming to Manchester, and we will be looking forward to it.”