The current holders will travel to the FA WSL 2 side in the fourth round on Sunday 4 February (time TBC).
City embark on the 2017/18 competition as reigning champions, having defeated Birmingham 4-1 at Wembley in May 2017.
Lucy Bronze, Izzy Christiansen, Carli Lloyd and Jill Scott were on the score-sheet in a stunning triumph - the Blues’ first success in the competition.
Managed by former England boss Hope Powell, Brighton & Hove Albion WFC currently play in the FA WSL 2 and their home ground is the Sussex FA HQ at Culver Road.
The Blues have never played the Seagulls before.
Ticket information for the trip to the south coast will be revealed in due course...
Full draw
Durham v Sheffield FC
Aston Villa v Middlesbrough
Sunderland v Derby County or Brighouse Town
Keynsham Town v Lewes
Tottenham Hotspur v Doncaster Rovers Belles
Liverpool v Watford
Cardiff City v Oxford United
The New Saints v Chichester City
Millwall v Coventry United
Reading v Birmingham City
Plymouth Argyle v Leicester City
Brighton & Hove Albion v Manchester City
Blackburn Rovers v Charlton Athletic
Yeovil Town v Arsenal
London Bees v Chelsea
Everton v Bristol City
