The tie will be played away and is the pick of the draw - but also represents a difficult hurdle for Gareth Taylor‘s side.
The Blues edged a step closer to Wembley with the 8-0 thrashing of Nottingham Forest at the weekend as City’s 2022 goal-glut continued.
Now the City will need to overcome our cross-city rivals to earn a quarter-final place.
We’ve only met United once before in the FAW Cup - a 3-2 away win in the fourth round in 2020, with Ellen White (2) and Jill Scott on the scoresheet.
It also means there will back-to-back Manchester derbies, with City hosting the Reds in the FAWSL a fortnight before.
The fifth round ties will be played on Sunday, 27 February.
Kick-off and ticket details will be confirmed in due course.
The full draw is:
Charlton Athletic v Everton
Durham v Birmingham City
West Brom v Coventry United
Reading v West Ham United
Chelsea v Leicester City
Manchester United v MANCHESTER CITY
Ipswich Town v Southampton FC Women
Liverpool v Arsenal